Slug-inspired glue patches beating hearts

A new glue inspired by slug slime can mend a broken heart.

The adhesive, described today (July 27) in a new study in the journal Science, sticks to wet surfaces, including the surface of a beating heart. It isn’t toxic to cells, which gives it an advantage over many surgical glues. It’s not available in operating rooms just yet — its developers say that could take years — but it could potentially be approved much more quickly for applications such as closing skin wounds.   

The slug-inspired glue is “very stretchy and very tough,” said Jianyu Li, a postdoctoral researcher at Harvard University’s Wyss Institute for Biologically Inspired Engineering and the lead author of the study. Li and his colleagues applied the adhesive to a blood-soaked, beating pig heart and found that it worked better than any other surgical glue on the market. 

Inspired by nature

The inspiration for the glue came from Arion subfuscus, a large and slimy species of slug found in North America and western Europe. These slugs excrete a sticky, yellow-orange slime that adheres well to wet surfaces. [7 Cool Technologies Inspired by Nature]

That characteristic intrigued Li and his colleagues, and they set to work making an artificial version of the slime. The key, Li told Live Science, is that the slime is made up of long, straight chains of molecules called polymers, which are also bound to each other — a phenomenon called cross-linking. Cross-linking makes materials strong, but the slug slime has the added advantage of having two types of cross-link bonds. Some were covalent bonds, which means they hold molecules together by sharing electrons. Others were ionic bonds, meaning one molecule hands over its electrons to another. These “hybridized” cross-links make the slug mucus both tough and stretchy, Li said.   

The team mimicked this structure using artificial polymers layered onto what they called a “dissipative matrix.” The polymers provide the sticking power,…

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