New Study Confirms Texas Fertility Center Research About Increasing Pregnancy Rates with Frozen Embryo Transfer

Kaylen M. Silverberg, M.D.

Frozen embryo transfers have been an integral part of our IVF practice for decades at Texas Fertility Center, and the new research in Fertility and Sterility confirms our initial research, as well as our shift to frozen embryo transfer protocols

A new study published in Fertility and Sterility in August compared the implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort study examined the contribution of progesterone and maternal age to IVF success.

After comparing the results from the fresh and frozen transfer cohorts, the authors of the study determined that freeze-only transfer protocols produce statistically significantly higher implantation and pregnancy rates compared with fresh cycles, especially when the woman has a progesterone level >1.0 ng/mL at trigger. The results remained consistent for women both above and below age 35.

The study has lead researchers to conclude that fertility specialists should shift their embryo transfer protocols from fresh to frozen, confirming the results of research that Texas Fertility Center published two decades ago.

The first to prove the link between progesterone production, FET and IVF success

In 1991, Kaylen Silverberg, M.D., the medical director of Texas Fertility Center, and other experts in the field evaluated the effect of premature progesterone production on pregnancy rates in IVF cycles. They concluded that even minimally increased progesterone production prior to ovulation trigger significantly lowered pregnancy rates. These findings were confirmed by several other studies, however, unlike Silverberg and his colleagues, those authors suggested that progesterone…

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